LncRNA LINC00240 suppresses invasion and migration in non-small cell lung cancer by sponging miR-7-5p

Abstract Background lncRNAs have important roles in regulating cancer biology. Accumulating evidence has established a link between the dysregulation of and microRNA progression. In previous studies, miR-7-5p been found to be significantly down-regulated mesenchymal-like lung cell lines directly regulated EGFR . this work, we investigated lncRNA partner progression cancer. Methods We expression after transfection with an mimics using microarray. The microarray results were validated quantitative real time-polymerase Chain Reaction (qRT-PCR). regulatory effects on its target evaluated by changes siRNAs for synthesis full-length lncRNA. effect miRNA was mimic inhibitor. role determined invasion migration assays. level normal tissue analyzed TCGA data. Results that LINC00240 downregulated line mimic. Further investigations revealed knockdown induced overexpression diminished migration. down siRNA treatment Silencing suppressed cells, whereas exerted opposite effect. lower squamous Conclusions Taken together, acted as sponge may represent potential